New research has identified the specific biological mechanism behind the muscle dysfunction found in myotonic dystrophy type 1 (DM1) and further shows that calcium channel blockers can reverse these ...
Researchers engineered mice with a mutation (E3896A) in the RyR1 calcium-binding site, eliminating calcium-induced calcium release (CICR) without affecting depolarization-induced calcium release. The ...
Managing Calcium Overload Identified as Novel Therapeutic Approach in Treating Injured Muscle Fibers
Mutations in a calcium ion channel anoctamin 5 (ANO5), commonly found in muscle cells, cause the debilitating disease called limb girdle muscular dystrophy 2L (LGMD2L). Characterized by progressive ...
This news release is available in German. Whenever muscles contract, so-called ryanodine receptors come into play. Calcium ions, which are ultimately responsible for the contraction of muscle cells, ...
When you have atrial fibrillation, the two upper chambers of your heart (atria) don't beat in sync with the two lower chambers (ventricles). This makes your heart beat out of rhythm and sometimes very ...
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