Directed evolution has enabled a high-performance biocatalyst to streamline synthesis of the HIV prevention drug lenacapavir ...

In nature, evolution takes years to sculpt new traits. In the lab, scientists hope to achieve this feat much faster: Being able to evolve proteins with enhanced or novel functions has important ...

From memory formation to disease prevention, scientists are uncovering how chromatin structure, enzyme evolution, and epigenetic regulators orchestrate gene activity. Recent breakthroughs reveal how ...

Enzymes originally evolved in high-temperature environments and later adapted to lower temperatures as Earth cooled. Scientists discovered that a key shift in enzyme function occurred over ...

Enzymes catalyze chemical reactions in organisms - without which life would not be possible. Leveraging AlphaFold2 artificial intelligence, researchers at Charité – Universitätsmedizin Berlin have now ...

Researchers at the Manchester Institute of Biotechnology (MIB) have used engineering biology—an emerging technology that uses ...

Recent trends in directed enzyme evolution focus on combining high-throughput screening methods with advanced biophysical tools and data-driven computational approaches. However, these methods pose ...

Laboratory evolution of a designer enzyme makes it into a much better catalyst . Simulations show that evolution does this by introducing networks of amino acids. These networks promise to be ...

Enzymes catalyze chemical reactions in organisms - without which life would not be possible. Leveraging AlphaFold2 artificial intelligence, researchers at Charité – Universitätsmedizin Berlin have now ...

With financial support from the Gates Foundation, researchers at the Manchester Institute of Biotechnology (MIB) have used engineering biology – an emerging technology that uses nature’s own processes ...