Efficient T-cell engineering is crucial for the success of CAR T-cell therapy research, but it requires multiple labor-intensive steps, including T-cell isolation, activation, and transduction.

(A) Schematic of T cell isolation and activation protocol. (B) Sample preparation, imaging, and analysis workflow using deep-UV microscopy. (C) Sample deep-UV images of CD4 T cells during a 21-d ...

Scientists have discovered that T cell receptors activate through a hidden spring-like motion that had never been seen before. This breakthrough may help explain why immunotherapy works for some ...