Introduction Severe asthma is characterised by inflammation and structural remodelling of the airways, typically resistant to standard therapies. Mepolizumab, an anti-IL-5 biologic, reduces eosinophil ...

Announcing a new article publication for BIO Integration journal. Alzheimer's disease (AD) is a neurodegenerative disorder and the leading cause of dementia worldwide. Microglia, as central nervous ...

Background Hepatocellular carcinoma (HCC) is a leading cause of cancer mortality with limited therapeutic options. Despite promising immunotherapy, response rates remain suboptimal. Tumour-associated ...

Introduction: Clonal hematopoiesis of indeterminate potential (CHIP) was recently shown to be an independent risk factor for immune checkpoint inhibitor (ICI)-associated myocarditis. However, the ...

Thanks for the amazing tool which I have been using on scRNA-seq and now on spatial transcriptomics data. I have one question about the CellChat v2 which expands to incorporate spatial locations into ...

Official support for free-threaded Python, and free-threaded improvements Python’s free-threaded build promises true parallelism for threads in Python programs by removing the Global Interpreter Lock ...

I am working with CellChat for cell-cell communication analysis. I have already built a cellchat object and performed the cell communication analysis using the entire dataset. Now, I would like to ...

We integrated single-cell RNA sequencing (scRNA-seq) data from primary tumors and metastatic lesions with bulk tissue transcriptomes and plasma-derived exosomal RNA sequencing (RNA-seq).