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Top 5 Most-Tested Microbiology Bugs & Their Treatments 1. Escherichia coli (E. coli)  Treatment highlights • EHEC: No antibiotics—management is supportive, as treatment can worsen hemolytic–uremic syndrome. • EPEC/EIEC etc.: Usually supportive or depends on specific subtype. • UTIs: Trimethoprim–sulfamethoxazole or nitrofurantoin for uncomplicated cases; IV broad-spectrum for complicated infections. • Neonatal meningitis: Ampicillin plus gentamicin (empiric regimen to cover E. coli and Listeria
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